Journal article
Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder
BJ Harrison, J Pujol, N Cardoner, J Deus, P Alonso, M López-Solà, O Contreras-Rodríguez, E Real, C Segalàs, L Blanco-Hinojo, JM Menchon, C Soriano-Mas
Biological Psychiatry | Published : 2013
Abstract
Background: Functional neuroimaging studies have provided consistent support for the idea that obsessive-compulsive disorder (OCD) is associated with disturbances of brain corticostriatal systems. However, in general, these studies have not sought to account for the disorder's prominent clinical heterogeneity. Methods: To address these concerns, we investigated the influence of major OCD symptom dimensions on brain corticostriatal functional systems in a large sample of OCD patients (n = 74) and control participants (n = 74) examined with resting-state functional magnetic resonance imaging. We employed a valid method for mapping ventral and dorsal striatal functional connectivity, which supp..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported, in part, by the Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (Fondo de Investigacion Sanitaria de la Seguridad Social (FIS), I.D. PI050884; PI071029; PI09/01331; PI10/01003; and CP10/00604), the Ministry of Education and Science of Spain (SAF2010-19434), and the Agencia de Gestio d'Ajusts Universitaris i de Recerca (2009SGR1554). BJH is supported by a National Health and Medical Research Council of Australia Clinical Career Development Award (I.D. 628509). CS-M is supported by a 'Miguel Servet' contract from the Carlos III Health Institute (I.D. CP10/00604). ER is supported by a "Rio Hortega" contract from the Carlos III Health Institute (I.D. CM11/00077). ML-S and JD are members of the Research Group SGR-1450 of the Agency of University and Research Funding Management of the Catalan Government. ML-S is supported by a Beatriu de Pinos Modalitat-A fellowship awarded by the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), Catalan Government (I.D. BP-A 00136). These funding bodies had no specific role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.